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Use of theophylline in chronic obstructive pulmonary disease: examining the evidence.
- Source :
-
Current opinion in pulmonary medicine [Curr Opin Pulm Med] 2006 Mar; Vol. 12 (2), pp. 132-9. - Publication Year :
- 2006
-
Abstract
- Purpose of Review: The role of theophylline in the management of chronic obstructive pulmonary disease remains controversial. This review was undertaken to determine the efficacy of theophylline in patients with stable disease.<br />Recent Findings: Twenty-two good quality randomized controlled trials were included in this systematic review. The review showed that theophylline significantly improved forced expiratory volume in 1 s and forced vital capacity (weighted mean difference 0.10 L; 95% confidence interval 0.04-0.16 and weighted mean difference 0.21 L; 95% confidence interval 0.10-0.31, respectively). V also improved with theophylline (weighted mean difference 195.27 mL/min; 95% confidence interval 112.71-277.83), as did Pa and Pa (weighted mean difference 1.45 mmHg; 95% confidence interval 0.26-2.65 and weighted mean difference -1.09 mmHg; 95% confidence interval -1.83 to -0.35, respectively). Patients preferred theophylline over placebo (relative risk 2.27; 95% confidence interval 1.26-4.11). Theophylline increased the risk of nausea, however, compared with placebo (relative risk 7.67; 95% confidence interval 1.47-39.94).<br />Summary: This review has shown that oral theophylline plays an important role in the management of patients with stable chronic obstructive pulmonary disease by improving lung function, arterial blood gas tensions and ventilatory capacity. Patients also preferred treatment with theophylline when compared with placebo. The benefits of theophylline in stable chronic obstructive pulmonary disease, however, have to be weighed against the risk of adverse effects, particularly nausea.
- Subjects :
- Double-Blind Method
Forced Expiratory Volume
Humans
Pulmonary Disease, Chronic Obstructive physiopathology
Randomized Controlled Trials as Topic
Treatment Outcome
Vital Capacity
Bronchodilator Agents therapeutic use
Pulmonary Disease, Chronic Obstructive drug therapy
Pulmonary Disease, Chronic Obstructive epidemiology
Theophylline therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1070-5287
- Volume :
- 12
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Current opinion in pulmonary medicine
- Publication Type :
- Academic Journal
- Accession number :
- 16456383
- Full Text :
- https://doi.org/10.1097/01.mcp.0000208453.95972.e2