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Risk factors associated with the need for additional intravenous gamma-globulin therapy for Kawasaki disease.
- Source :
-
Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2006 Feb; Vol. 95 (2), pp. 189-93. - Publication Year :
- 2006
-
Abstract
- Aim: To investigate the characteristics of patients with Kawasaki disease who needed intravenous gamma-globulin (IVGG) re-treatment.<br />Methods: Using the database of the 17th nationwide survey in Japan, a total 11,366 patients were identified and analysed (1,855 re-treatment patients and 9,511 responders).<br />Results: Multivariate logistic regression analysis showed that male sex (odds ratio (OR) 1.26; 95% CI 1.14-1.40), complete cases (OR 1.39; 95% CI 1.07-1.80), recurrence (OR 1.47; 95% CI 1.15-1.88), IVGG treatment within 4 d of illness (OR 2.05; 95% CI 1.84-2.27), daily dose of initial IVGG less than 1,000 mg/Kg (OR 0.54; 95% CI 0.48-0.61), exanthema (OR 2.03; 95% CI 1.62-2.56), lips and oral lesions (OR 1.57; 95% CI 1.24-1.98), peripheral extremities changes (OR 1.85; 95% CI 1.54-2.22), and cervical lymphadenopathy (OR 1.89; 95% CI 1.66-2.16) were independent risk factors associated with the need for IVGG re-treatment.<br />Conclusion: Male sex, recurrence, and treatment with IVGG at a dose of 1,000 mg/d or less within 4 d of illness onset are independent risk factors associated with the need for IVGG re-treatment.
- Subjects :
- Exanthema epidemiology
Female
Humans
Immunoglobulins, Intravenous
Injections, Intravenous
Logistic Models
Lymphatic Diseases epidemiology
Male
Mucocutaneous Lymph Node Syndrome epidemiology
Recurrence
Risk Factors
gamma-Globulins administration & dosage
Health Services Needs and Demand
Mucocutaneous Lymph Node Syndrome drug therapy
gamma-Globulins therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0803-5253
- Volume :
- 95
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Acta paediatrica (Oslo, Norway : 1992)
- Publication Type :
- Academic Journal
- Accession number :
- 16449025
- Full Text :
- https://doi.org/10.1080/08035250500327328