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Coronary vasomotor response to the selective B1-kinin-receptor agonist Des-Arg9-bradykinin in humans.
- Source :
-
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation [J Heart Lung Transplant] 2006 Feb; Vol. 25 (2), pp. 187-94. - Publication Year :
- 2006
-
Abstract
- Objectives: The aim of the present study was to assess the effects of selective B1-receptor stimulation with des-Arg9-bradykinin on coronary vasomotion in transplanted and non-transplanted patients.<br />Background: Bradykinin B1-receptors have been identified on endothelial and smooth muscle cells in human coronary arteries in vitro; however, their physiologic role in the coronary circulation is unknown.<br />Methods: Twelve heart transplant patients were compared with 10 control subjects at 3.2 +/- 2.2 months after surgery. Coronary flow velocity was measured using guide-wire Doppler. The diameter of 3 epicardial segments of the left coronary artery and coronary blood flow were assessed at baseline, immediately after infusions of increasing doses of des-arginine(Arg9)-bradykinin at estimated coronary blood concentrations of 5.4 x 10(-9), 5.4 x 10(-8), 5.4 x 10(-7) and 1.6 x 10(-6) mol/liter, and of acetylcholine at 10(-8), 10(-7) and 10(-6) mol/liter).<br />Results: Des-Arg9-bradykinin induced a similar decrease in all measured epicardial diameters in both groups and no change in coronary blood flow. Vasoconstriction was significant only at the 2 highest concentrations: -6 +/- 9% (p < 0.01) and -7 +/- 11% (p < 0.01) in control subjects, and -8 +/- 8% (p < 0.001) and -9 +/- 11% (p < 0.001) in heart transplant patients. Acetylcholine induced significant epicardial vasodilation in control subjects and vasoconstriction in transplant patients. The presence of allograft rejection did not modify the responses to des-Arg9-bradykinin with regard to both conductance and resistance vessels.<br />Conclusions: Kinin B1-receptors exist and can be stimulated in humans. The vasoconstrictive action on epicardial coronary arteries of des-Arg(9)-bradykinin in humans argues for a predominant action of B1-receptor stimulation at the level of smooth muscle cells.
- Subjects :
- Acetylcholine pharmacology
Adult
Blood Flow Velocity drug effects
Blood Flow Velocity physiology
Bradykinin pharmacology
Coronary Angiography
Coronary Vessels drug effects
Coronary Vessels physiology
Dose-Response Relationship, Drug
Endothelium, Vascular chemistry
Endothelium, Vascular physiology
Female
Heart Transplantation physiology
Hemodynamics physiology
Humans
Male
Middle Aged
Molsidomine analogs & derivatives
Molsidomine pharmacology
Muscle, Smooth, Vascular chemistry
Muscle, Smooth, Vascular physiology
Receptor, Bradykinin B1 analysis
Receptor, Bradykinin B2 analysis
Vasoconstriction physiology
Vasodilation physiology
Vasodilator Agents pharmacology
Bradykinin analogs & derivatives
Receptor, Bradykinin B1 agonists
Receptor, Bradykinin B1 physiology
Receptor, Bradykinin B2 agonists
Receptor, Bradykinin B2 physiology
Vasoconstriction drug effects
Vasodilation drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1557-3117
- Volume :
- 25
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 16446219
- Full Text :
- https://doi.org/10.1016/j.healun.2005.08.020