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Long-term L-NAME treatment potentiates the blood-brain barrier disruption during pentylenetetrazole-induced seizures in rats.
- Source :
-
Life sciences [Life Sci] 2006 May 30; Vol. 79 (1), pp. 16-20. Date of Electronic Publication: 2006 Jan 24. - Publication Year :
- 2006
-
Abstract
- We investigated whether the severity of blood-brain barrier disruption caused by pentylenetetrazole-induced seizures is modified by long-term nitric oxide synthase inhibition in rats. Rats were given N-omega-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, in drinking water for 4 weeks, and then treated with pentylenetetrazole to induce seizures. Damage to the blood-brain barrier was investigated using Evans blue dye extravasation. Serum nitric oxide concentration was decreased in L-NAME-treated rats (P<0.01). L-NAME and/or pentylenetetrazole treatments elevated systolic blood pressure of animals (P<0.01). L-NAME caused an increase in the mortality rate after pentylenetetrazole injection leading to the death of animals at about 15 min after the onset of the seizure. Pentylenetetrazole-induced seizures in rats treated with L-NAME caused a significant increase in Evans blue dye extravasation into cerebral cortex, diencephalon and cerebellum, as compared with seizures evoked by pentylenetetrazole injection to L-NAME-untreated rats (P<0.01). Data presented here suggest that the degree of blood-brain barrier disruption induced by seizures is more pronounced in long-term nitric oxide deficiency.
- Subjects :
- Animals
Blood Pressure drug effects
Drug Synergism
Evans Blue
Male
Nitric Oxide metabolism
Rats
Rats, Wistar
Blood-Brain Barrier drug effects
Convulsants pharmacology
Enzyme Inhibitors pharmacology
NG-Nitroarginine Methyl Ester pharmacology
Pentylenetetrazole pharmacology
Seizures chemically induced
Seizures metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0024-3205
- Volume :
- 79
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 16438992
- Full Text :
- https://doi.org/10.1016/j.lfs.2005.12.034