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A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities.
- Source :
-
FEBS letters [FEBS Lett] 2006 Feb 06; Vol. 580 (3), pp. 839-43. Date of Electronic Publication: 2006 Jan 18. - Publication Year :
- 2006
-
Abstract
- The cysteine in the M/IXXCW motif is conserved in all but one (threonine in place of cysteine) of the human protein tyrosine kinases (PTKs). We showed that all RET-PTC-1 mutants in which the C in this motif (C376) was replaced with glycine, lysine, threonine or serine lost their activity in vitro. However, the C376T/S mutants showed normal tyrosine phosphorylation in vivo (in cells). Further analyses reveled that protein kinase C (PKC) initiated the activities of the C376T/S mutants in cells. We conclude that the M/IXXCW motif-mediated mechanisms which initiate PTK activities are partially replaced by a PKC-mediated mechanism.
Details
- Language :
- English
- ISSN :
- 0014-5793
- Volume :
- 580
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 16427628
- Full Text :
- https://doi.org/10.1016/j.febslet.2006.01.005