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Variations in plasmacytoid dendritic cell (PDC) and myeloid dendritic cell (MDC) levels in HIV-infected subjects on and off antiretroviral therapy.
- Source :
-
Journal of clinical immunology [J Clin Immunol] 2006 Jan; Vol. 26 (1), pp. 55-64. - Publication Year :
- 2006
-
Abstract
- Plasmacytoid and myeloid dendritic cells are reduced in AIDS patients. The number of these circulating cells was assessed cross-sectionally and longitudinally in 27 uninfected and 72 HIV-infected subjects on and off antiretroviral therapy. The plasmacytoid dendritic cell numbers were significantly reduced in the HIV-infected subjects compared to controls (p < 0.001). This reduction correlated directly with CD4+ cell counts (p < 0.001) and inversely with viral load (p < 0.001). These associations were found to a lesser degree for the myeloid dendritic cells. Intra-assay variability of these dendritic cell counts was < 10%. Antiretroviral therapy significantly increased plasmacytoid dendritic cell (p < 0.001) and CD4+ cell (p = 0.05) counts at 8 months by 76.9% and 19%, respectively. The plasmacytoid dendritic cell levels responded more readily to viral load increases and decreases than CD4+ cells. Circulating plasmacytoid dendritic cells may provide important additional information about immune function in HIV-infected subjects receiving or not receiving antiretroviral therapy.
- Subjects :
- Adult
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes chemistry
Cell Count
Cohort Studies
Female
HIV Infections drug therapy
HIV Infections immunology
Humans
Male
Middle Aged
Myeloid Cells immunology
Plasma Cells immunology
Viral Load
Anti-Retroviral Agents therapeutic use
Antiretroviral Therapy, Highly Active
Dendritic Cells immunology
HIV Infections blood
Subjects
Details
- Language :
- English
- ISSN :
- 0271-9142
- Volume :
- 26
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of clinical immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16418803
- Full Text :
- https://doi.org/10.1007/s10875-006-8401-3