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CD4 T cell activation as a predictor for treatment failure in Ugandans with Plasmodium falciparum malaria.
- Source :
-
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2006 Jan; Vol. 74 (1), pp. 41-3. - Publication Year :
- 2006
-
Abstract
- Host immunity plays an important role in response to antimalarial therapy but is poorly understood. To test whether T cell activation is a risk factor for antimalarial treatment failure, we studied CD4(+) and CD8(+) T cell activation in 31 human immunodeficiency virus-negative Ugandan patients 5-37 years of age who were treated for uncomplicated Plasmodium falciparum malaria. Increased CD4(+) T cell activation, as indicated by co-expression of HLA-DR and CD38, was an independent risk factor for treatment failure (hazard ratio = 2.45, 95% confidence interval = 1.02-5.89, P = 0.05) in multivariate analysis controlling for age, baseline temperature, and pre-treatment parasite density. The results provide insight into the role of cellular immunity in response to antimalarial therapy and underscore the need to investigate the mechanisms behind immune activation.
- Subjects :
- Adolescent
Adult
Age Factors
Animals
Body Temperature
CD8-Positive T-Lymphocytes physiology
Child
Child, Preschool
Chloroquine therapeutic use
Drug Combinations
Female
Humans
Male
Parasitemia
Plasmodium falciparum immunology
Pyrimethamine therapeutic use
Risk Factors
Sulfadoxine therapeutic use
Treatment Failure
Uganda
Antimalarials therapeutic use
CD4-Positive T-Lymphocytes immunology
Lymphocyte Activation
Malaria, Falciparum drug therapy
Malaria, Falciparum immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9637
- Volume :
- 74
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The American journal of tropical medicine and hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 16407344