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Mechanisms of pericyte recruitment in tumour angiogenesis: a new role for metalloproteinases.
- Source :
-
European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2006 Feb; Vol. 42 (3), pp. 310-8. Date of Electronic Publication: 2006 Jan 10. - Publication Year :
- 2006
-
Abstract
- Pericytes occur in tumour blood vessels and are critical for the development of a functional vascular network. Targeting tumour pericytes is a promising anti-angiogenic therapy but requires identifying the mechanisms of their recruitment in tumour and addressing whether these mechanisms can be selectively harnessed. Among the pathways involved in pericyte recruitment during embryonic development, the contribution of platelet-derived growth factor B and sphingosine 1-phosphate is confirmed in tumour angiogenesis. The effect of angiopoietin 1 depends on the tumour model. Transforming growth factor-beta1 enhances tumour vascularization and microvessel maturation. Recent reports suggest a participation of matrix metalloproteinases (MMP) in tumour pericyte recruitment that is consistent with the effect of certain MMPs in the development of microvasculature in embryonic development and in in vitro models of vascular remodelling. Here, we discuss the possibility for MMPs to contribute to pericyte recruitment at six levels: (1) direct promotion of pericyte invasion by extracellular matrix degradation; (2) stimulation of pericyte proliferation and protection against apoptosis by modification of the ECM; (3) activation of pericytes through the release of growth factor bound to the ECM; (4) transactivation of angiogenic cell surface receptor; (5) propagation of angiogenic signalling as cofactor; and (6) recruitment of bone marrow-derived stem cells.
- Subjects :
- Angiopoietin-1 physiology
Cell Movement physiology
Cell Proliferation
Humans
Lysophospholipids physiology
Proto-Oncogene Proteins c-sis physiology
Sphingosine analogs & derivatives
Sphingosine physiology
Transforming Growth Factor beta physiology
Transforming Growth Factor beta1
Matrix Metalloproteinases physiology
Neoplasms blood supply
Neovascularization, Pathologic drug therapy
Pericytes physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0959-8049
- Volume :
- 42
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of cancer (Oxford, England : 1990)
- Publication Type :
- Academic Journal
- Accession number :
- 16406506
- Full Text :
- https://doi.org/10.1016/j.ejca.2005.11.010