Fatal outcome of herpes simplex virus type 1-induced necrotic hepatitis in a neonate.

Authors :: Meerbach A
Sauerbrei A
Meerbach W
Bittrich HJ
Wutzler P
Source :: Medical microbiology and immunology [Med Microbiol Immunol] 2006 Jun; Vol. 195 (2), pp. 101-5. Date of Electronic Publication: 2006 Jan 11.
Publication Year :: 2006
Abstract: In neonates, herpes simplex virus (HSV) infections can lead to severe diseases associated with high mortality. We report a 6-day-old girl who developed clinical signs of fulminant hepatic failure accompanied by infectious-toxic shock and disseminated coagulopathy secondary to HSV type 1 (HSV-1) infection. The diagnosis was performed postmortem by demonstration of HSV-1 DNA in liver tissue as well as by retrospective detection of HSV-specific antibodies.

Subjects :: Antibodies, Viral blood
Disseminated Intravascular Coagulation
Fatal Outcome
Female
Hepatitis, Viral, Human mortality
Hepatitis, Viral, Human pathology
Herpes Simplex mortality
Herpes Simplex virology
Humans
Infant, Newborn
Liver pathology
Liver virology
Liver Failure, Acute
Necrosis
Hepatitis, Viral, Human virology
Herpes Simplex complications
Herpesvirus 1, Human

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