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Forearm vascular response to nitric oxide and calcitonin gene-related peptide: comparison between migraine patients and control subjects.
- Source :
-
Cephalalgia : an international journal of headache [Cephalalgia] 2006 Jan; Vol. 26 (1), pp. 56-63. - Publication Year :
- 2006
-
Abstract
- The forearm vascular response to nitric oxide (NO) and calcitonin gene-related peptide (CGRP) was investigated in 10 migraine patients and 10 matched control subjects. Changes in forearm blood flow (FBF) during intrabrachial infusion of: (i) serotonin (releasing endogenous NO), (ii) sodium nitroprusside (SNP, exogenous NO-donor), and (iii) CGRP were measured using venous occlusion plethysmography. Flow-mediated dilation (FMD) of the brachial artery, a measure for the endogenous release of NO reactive to occlusion, was measured using ultrasound and expressed as percentage change vs. baseline diameter. FBF ratio (i.e. FBF in the infused over the control arm) at baseline (1.1 +/- 0.1) did not differ between both populations. Serotonin, SNP and CGRP induced a dose-dependent increase (P < 0.001) in FBF ratio in controls (to 2.8 +/- 0.3, 6.7 +/- 1.4 and 6.9 +/- 1.2 at the highest dose, respectively) and migraineurs (2.5 +/- 0.4, 5.6 +/- 0.8 and 6.5 +/- 1.3, respectively); these ratios did not differ between both groups. FMD was comparable in control subjects (5.8 +/- 1%) and migraine patients (5.2 +/- 1%). Based on the forearm vascular response to NO and CGRP, migraine patients do not display generalized changes in vascular function.
- Subjects :
- Adult
Brachial Artery physiology
Female
Forearm blood supply
Humans
Ischemia metabolism
Ischemia physiopathology
Male
Migraine Disorders etiology
Migraine Disorders metabolism
Nitric Oxide Donors administration & dosage
Nitroprusside administration & dosage
Plethysmography
Serotonin administration & dosage
Serotonin Agents administration & dosage
Vasodilation drug effects
Calcitonin Gene-Related Peptide administration & dosage
Migraine Disorders physiopathology
Nitric Oxide metabolism
Regional Blood Flow drug effects
Regional Blood Flow physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0333-1024
- Volume :
- 26
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cephalalgia : an international journal of headache
- Publication Type :
- Academic Journal
- Accession number :
- 16396667
- Full Text :
- https://doi.org/10.1111/j.1468-2982.2005.00993.x