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Antitumor effects of IDN5109 on head and neck squamous cell carcinoma.
- Source :
-
Oncology reports [Oncol Rep] 2006 Feb; Vol. 15 (2), pp. 329-34. - Publication Year :
- 2006
-
Abstract
- Taxanes, a new class of antitumor drugs, are effective against a large number of human tumors, although there are problems with drug resistance. The novel taxane, IDN5109, is characterized by its high tolerability, antitumor efficacy, ability to overcome multidrug resistance, and oral bioavailabilty. We investigated the cellular response of IDN5109 to head and neck squamous cell carcinoma (HNSCC), and compared the antitumor activity of IDN5109 with that of paclitaxel. This is the first demonstration of antitumor effects of IDN5109 on HNSCC. In in vitro experiments, IDN5109 showed antiproliferative effects against HNSCC cell lines. After treatment with IDN5109, Bcl-2 and Bcl-XL were down-regulated, Bax was up-regulated, and caspase-3 was activated. After treatment with IDN5109, concentrations of both VEGF and IL-8 in the culture supernatant of HNSCC cells decreased. In in vivo experiments, the oral administration of IDN5109 showed antitumor effects against HNSCC tumor xenografts. Immunohistochemistry showed that IDN5109 inhibited tumor angiogenesis and induced apoptosis in HNSCC cells, producing a decreased blood vessel density and increased apoptosis index. On the basis of these results, IDN5109 is useful as a chemotherapeutic agent against HNSCC.
- Subjects :
- Blotting, Western
Cell Line, Tumor
Humans
Paclitaxel therapeutic use
Antineoplastic Agents therapeutic use
Apoptosis drug effects
Bridged-Ring Compounds therapeutic use
Carcinoma, Squamous Cell drug therapy
Cell Proliferation drug effects
Head and Neck Neoplasms drug therapy
Neovascularization, Pathologic drug therapy
Taxoids therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1021-335X
- Volume :
- 15
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Oncology reports
- Publication Type :
- Academic Journal
- Accession number :
- 16391850