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Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Mar 15; Vol. 16 (6), pp. 1696-701. Date of Electronic Publication: 2005 Dec 27. - Publication Year :
- 2006
-
Abstract
- A series of indole-O-glucosides and C-glucosides was synthesized and evaluated in SGLT1 and SGLT2 cell-based functional assays. Compounds 2a and 2o were identified as potent SGLT2 inhibitors and screened in ZDF rats.
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 16
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 16380256
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.12.006