Back to Search
Start Over
An endophytic fungus from Nothapodytes foetida that produces camptothecin.
- Source :
-
Journal of natural products [J Nat Prod] 2005 Dec; Vol. 68 (12), pp. 1717-9. - Publication Year :
- 2005
-
Abstract
- A fungal endophytic isolate, camptothecin, has been isolated from the inner bark of the plant Nothapodytes foetidafrom the Western coast of India. The fungus, which belongs to the family Phycomycetes, produced the anticancer drug lead compound camptothecin (1) when grown in a synthetic liquid medium (Sabouraud broth) under shake flask and bench scale fermentation conditions. Compound 1 was identified by means of chromatographic and spectroscopic methods. It was also compared with an authentic example for its biological activity against a number of human cancer cell lines. Isolation of an organism producing 1 and its fermentation may, in the future, provide an easily accessible source for the production of this anticancer drug precursor molecule.
- Subjects :
- Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Camptothecin chemistry
Camptothecin pharmacology
Cell Line, Tumor
Chromatography, High Pressure Liquid
DNA, Fungal isolation & purification
Drug Screening Assays, Antitumor
Humans
India
Molecular Structure
Plant Bark
Antineoplastic Agents isolation & purification
Camptothecin isolation & purification
Phycomyces chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0163-3864
- Volume :
- 68
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 16378360
- Full Text :
- https://doi.org/10.1021/np0502802