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Outcome, incidence, and timing of infectious complications in small bowel and multivisceral organ transplantation patients.
- Source :
-
Transplantation [Transplantation] 2005 Dec 27; Vol. 80 (12), pp. 1742-8. - Publication Year :
- 2005
-
Abstract
- Background: Infectious complications still represent a major cause of morbidity and mortality in patients with organ transplantation. In particular, small bowel or multivisceral transplantation is complicated to a greater extent than other grafts as a consequence of infectious complications including sepsis.<br />Methods: This prospective study assessed outcome, incidence, and timing of infections in sequential patients undergoing small bowel or multivisceral transplantation (SB/MVTx) performed at a university transplant center between January 2001 and October 2003. Nineteen patients underwent transplantation during this period, 13 of whom (68%) undergoing isolated SB and 6 (32%) MV grafts with or without liver.<br />Results: The median follow up was 524 days (interquartile range=252-730) with an overall 24.4 person/year of observation. Postoperative mortality rate was 0.1 death/person/year; all patients, except one who died intraoperatively, were alive 6 months postsurgery. There were 100 documented infections including: 59 bacterial (2.4 events/person/year), 35 viral (1.4 events/person/year) and 6 fungal (0.2 events/person/year). Patients developed at least one episode of bacterial infection in 94% of the cases, viral infection in 67%, and fungal infection in 28%.<br />Conclusions: This cohort describes the very common and complex nature of infectious complications in this challenging group of transplantation patients. Larger cohorts are needed to specifically address infection risk factors and longer term outcomes.
- Subjects :
- Adult
Bacterial Infections epidemiology
Blood Transfusion
Cause of Death
Female
Follow-Up Studies
Graft Rejection epidemiology
Humans
Incidence
Liver Transplantation adverse effects
Liver Transplantation mortality
Male
Mycoses epidemiology
Reoperation
Retrospective Studies
Survival Analysis
Time Factors
Transplantation, Homologous mortality
Treatment Outcome
Virus Diseases epidemiology
Intestine, Small transplantation
Postoperative Complications epidemiology
Surgical Wound Infection epidemiology
Transplantation, Homologous adverse effects
Viscera transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 0041-1337
- Volume :
- 80
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 16378070
- Full Text :
- https://doi.org/10.1097/01.tp.0000185622.91708.57