Back to Search
Start Over
Sensitivity-enhanced 13C MR spectroscopy of the human brain at 3 Tesla.
- Source :
-
Magnetic resonance in medicine [Magn Reson Med] 2006 Feb; Vol. 55 (2), pp. 271-8. - Publication Year :
- 2006
-
Abstract
- A new coil design for sensitivity-enhanced 13C MR spectroscopy (MRS) of the human brain is presented. The design includes a quadrature transmit/receive head coil optimized for 13C MR sensitivity. Loss-less blocking circuits inside the coil conductors allow this coil to be used inside a homogeneous circularly polarized 1H B1 field for 1H decoupled 13C MRS. A quadrature 1H birdcage coil optimized for minimal local RF heating makes broadband 1H decoupling in the entire human brain possible at 3 Tesla while remaining well within international safety guidelines for RF absorption. Apart from a substantial increase in sensitivity compared to conventional small linear coils, the quadrature 13C coil combined with the quadrature 1H birdcage coil allows efficient cross polarization (CP) in the brain, resulting in an additional 3.5-fold sensitivity improvement compared to direct 13C measurements without nuclear Overhauser enhancement (NOE) or polarization transfer. Combined with the gain in power efficiency, this setup allows broadband 1H to 13C CP over large areas of the brain. Clear 13C resonances from glutamate (Glu), glutamine (Gln), aspartate (Asp), lactate (Lac), and gamma-aminobutyrate (GABA) carbon spins in the human brain demonstrate the quality of 13C MR spectra obtained in vivo with this coil setup.<br /> (Copyright 2006 Wiley-Liss, Inc.)
- Subjects :
- Aspartic Acid chemistry
Carbon Isotopes
Glutamic Acid chemistry
Glutamine chemistry
Humans
Image Enhancement methods
Lactates chemistry
Sensitivity and Specificity
Signal Processing, Computer-Assisted
gamma-Aminobutyric Acid chemistry
Brain Chemistry
Magnetic Resonance Spectroscopy instrumentation
Subjects
Details
- Language :
- English
- ISSN :
- 0740-3194
- Volume :
- 55
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Magnetic resonance in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 16372278
- Full Text :
- https://doi.org/10.1002/mrm.20745