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Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma.
- Source :
-
Nature immunology [Nat Immunol] 2006 Feb; Vol. 7 (2), pp. 207-15. Date of Electronic Publication: 2005 Dec 20. - Publication Year :
- 2006
-
Abstract
- B cell differentiation is controlled by a complex network of lineage-restricted transcription factors. How perturbations to this network alter B cell fate remains poorly understood. Here we show that classical Hodgkin lymphoma tumor cells, which originate from mature B cells, have lost the B cell phenotype as a result of aberrant expression of transcriptional regulators. The B cell-specific transcription factor program was disrupted by overexpression of the helix-loop-helix proteins ABF-1 and Id2. Both factors antagonized the function of the B cell-determining transcription factor E2A. As a result, expression of genes specific to B cells was lost and expression of genes not normally associated with the B lineage was upregulated. These data demonstrate the plasticity of mature human lymphoid cells and offer an explanation for the unique classical Hodgkin lymphoma phenotype.
- Subjects :
- B-Lymphocytes immunology
B-Lymphocytes pathology
Base Sequence
Basic Helix-Loop-Helix Transcription Factors genetics
Cell Line, Tumor
Dimerization
Gene Expression
Hodgkin Disease genetics
Hodgkin Disease immunology
Hodgkin Disease pathology
Humans
Inhibitor of Differentiation Protein 2 genetics
Multiprotein Complexes
PAX5 Transcription Factor genetics
PAX5 Transcription Factor metabolism
Phenotype
RNA, Messenger genetics
RNA, Messenger metabolism
RNA, Neoplasm genetics
RNA, Neoplasm metabolism
B-Lymphocytes metabolism
Basic Helix-Loop-Helix Transcription Factors antagonists & inhibitors
Basic Helix-Loop-Helix Transcription Factors metabolism
Hodgkin Disease metabolism
Inhibitor of Differentiation Protein 2 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2908
- Volume :
- 7
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nature immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16369535
- Full Text :
- https://doi.org/10.1038/ni1285