Back to Search
Start Over
pH-sensitive vesicles based on a biocompatible zwitterionic diblock copolymer.
- Source :
-
Journal of the American Chemical Society [J Am Chem Soc] 2005 Dec 28; Vol. 127 (51), pp. 17982-3. - Publication Year :
- 2005
-
Abstract
- Highly biocompatible pH-sensitive diblock copolymer vesicles were prepared from the self-assembly of a biocompatible zwitterionic copolymer, poly[2-(methacryloyloxy)ethyl phosphorylcholine-block-2-(diisopropylamino)ethyl methacrylate], PMPC-b-PDPA. Vesicle formation occurred spontaneously by adjusting the solution pH from pH 2 to above 6, with the hydrophobic PDPA chains forming the vesicle walls. Transmission electron microscopy (TEM), dynamic laser light scattering (DLS), and UV-visible absorption spectrophotometry were used to characterize these vesicles. Gold nanoparticle-decorated vesicles were also obtained by treating the vesicles with HAuCl4, followed by NaBH4.
Details
- Language :
- English
- ISSN :
- 0002-7863
- Volume :
- 127
- Issue :
- 51
- Database :
- MEDLINE
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 16366531
- Full Text :
- https://doi.org/10.1021/ja056514l