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Spontaneous ophthalmic diseases in 586 New Zealand white rabbits.
- Source :
-
Experimental animals [Exp Anim] 2005 Oct; Vol. 54 (5), pp. 395-403. - Publication Year :
- 2005
-
Abstract
- The purpose of this study was to investigate spontaneous eye disease in New Zealand White (NZW) rabbits, which are commonly used for toxicity tests, and to provide reference materials for pharmaceutical companies and research centers. A total of 586 NZW rabbits were randomly chosen without sex preference and were examined using ocular equipment, including a direct ophthalmoscope, an indirect ophthalmoscope, a slit-lamp biomicroscope, a focal illuminator, and a fundus camera. This study showed that the incidence rate of temporary cataracts, regarded as a change within normal variation, was 0.5% in the NZW rabbits. Regarding abnormal ophthalmic disease, blepharitis was the most commonly observed ocular disease. Other findings included cataract, conjunctivitis, choroidal hypoplasia, keratitis, corneal scarring, eyelid laceration, posterior synechiae, uveitis, dacryocystitis, and persistent pupillary membrane. In total, the incidence rate of ophthalmic diseases was 9.6%. Based on sex and age distributions, females had more ocular diseases than males, and rabbits were less susceptible to eye diseases as they got older. In this study, photographs were taken to document findings, such as normal fundus, normal variations, ophthalmic disease, and histopathologic examination.
- Subjects :
- Animals
Animals, Laboratory
Blepharitis epidemiology
Blepharitis pathology
Blepharitis veterinary
Cataract epidemiology
Cataract pathology
Cataract veterinary
Conjunctivitis epidemiology
Conjunctivitis pathology
Conjunctivitis veterinary
Diagnostic Techniques, Ophthalmological
Eye pathology
Eye Abnormalities epidemiology
Eye Abnormalities pathology
Eye Abnormalities veterinary
Eye Diseases epidemiology
Eye Diseases pathology
Female
Keratitis epidemiology
Keratitis pathology
Keratitis veterinary
Male
Sex Factors
Eye Diseases veterinary
Rabbits
Subjects
Details
- Language :
- English
- ISSN :
- 1881-7122
- Volume :
- 54
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Experimental animals
- Publication Type :
- Academic Journal
- Accession number :
- 16365516
- Full Text :
- https://doi.org/10.1538/expanim.54.395