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Stromal syndecan-1 expression is an adverse prognostic factor in oral carcinomas.
- Source :
-
Oral oncology [Oral Oncol] 2006 May; Vol. 42 (5), pp. 493-500. Date of Electronic Publication: 2005 Dec 20. - Publication Year :
- 2006
-
Abstract
- Syndecan-1, a transmembrane proteoglycan, may exert anti-proliferative effects and promote cell growth by binding various growth factors. Malignant epithelial cells often down-regulate their own syndecan-1 production, and are capable of inducing an aberrant syndecan-1 expression in stromal fibroid cells. Decreased tumor cell syndecan-1 levels in human head and neck squamous cell carcinomas indicate poor prognosis, however, no correlation between stromal syndecan-1 expression and clinical parameters has previously been established. By means of immunohistochemistry, we observed a decrease in tumor cell syndecan-1 reactivity in 33/39 oral carcinoma cases, the degree of which, however, correlated only weakly with the clinical outcome (p = 0.097). Conversely, stromal syndecan-1 positivity proved to be a significant risk factor of recurrence (Cox analysis, p = 0.03) and tumor-specific death (p = 0.023) within a 24-month period after operation. Taken together, stromal expression of syndecan-1 is a reliable factor of adverse prognosis in oral carcinomas.
- Subjects :
- Adult
Aged
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell secondary
Carcinoma, Squamous Cell therapy
Female
Humans
Immunoenzyme Techniques
Male
Middle Aged
Mouth Neoplasms pathology
Mouth Neoplasms therapy
Neoplasm Proteins metabolism
Neoplasm Recurrence, Local
Neoplasm Staging
Prognosis
Stromal Cells metabolism
Survival Analysis
Tongue Neoplasms metabolism
Tongue Neoplasms pathology
Tongue Neoplasms therapy
Treatment Outcome
Biomarkers, Tumor metabolism
Carcinoma, Squamous Cell metabolism
Mouth Neoplasms metabolism
Syndecan-1 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1368-8375
- Volume :
- 42
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Oral oncology
- Publication Type :
- Academic Journal
- Accession number :
- 16364677
- Full Text :
- https://doi.org/10.1016/j.oraloncology.2005.10.003