Back to Search
Start Over
Altered discharges of spinal wide dynamic range neurons and down-regulation of glutamate transporter expression in rats with paclitaxel-induced hyperalgesia.
- Source :
-
Neuroscience [Neuroscience] 2006; Vol. 138 (1), pp. 329-38. Date of Electronic Publication: 2005 Dec 19. - Publication Year :
- 2006
-
Abstract
- Changes in the signaling of wide dynamic range neurons and the expression of glutamate transporters in the lumbar spinal dorsal horn of rats with Taxol-induced hyperalgesia are detailed in this report. Deep spinal lamina neurons have significantly increased spontaneous activity and after-discharges to noxious mechanical stimuli, increased responses to both skin heating and cooling, and increased after-discharges and abnormal windup to transcutaneous electrical stimuli. The expression of glutamate transporter proteins in the dorsal horn is decreased at the time point corresponding to the physiological changes. These results suggest a state of increased excitability develops in spinal pain-signaling neurons as a consequence of decreased glutamate clearance. These changes in dorsal horn neurobiology likely in turn contribute to the hyper-responsiveness to sensory stimuli seen in animals treated with Taxol and may play a role in the pain seen in cancer patients receiving Taxol.
- Subjects :
- Amino Acid Transport System X-AG genetics
Animals
Behavior, Animal drug effects
Data Interpretation, Statistical
Down-Regulation drug effects
Down-Regulation physiology
Electric Stimulation
Electrophysiology
Evoked Potentials drug effects
Hot Temperature
Hyperalgesia metabolism
Hyperalgesia physiopathology
Immunohistochemistry
Male
Neurons drug effects
Pain Measurement drug effects
Peripheral Nervous System Diseases chemically induced
Peripheral Nervous System Diseases pathology
Physical Stimulation
Posterior Horn Cells drug effects
Rats
Rats, Sprague-Dawley
Spinal Cord cytology
Spinal Cord drug effects
Amino Acid Transport System X-AG biosynthesis
Antineoplastic Agents, Phytogenic
Hyperalgesia chemically induced
Neurons physiology
Paclitaxel
Spinal Cord physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0306-4522
- Volume :
- 138
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 16361064
- Full Text :
- https://doi.org/10.1016/j.neuroscience.2005.11.009