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Concepts, facts and artifacts in electron microscopy.
- Source :
-
Cellular and molecular biology (Noisy-le-Grand, France) [Cell Mol Biol (Noisy-le-grand)] 2005 Dec 16; Vol. 51 (8), pp. 775-88. Date of Electronic Publication: 2005 Dec 16. - Publication Year :
- 2005
-
Abstract
- This communication illustrates how the electron microscope has contributed to biochemistry by revealing how multienzyme systems in mitochondria are structurally organized to secure high speed ATP synthesis and has extended physiology to the molecular level. Ribonucleoprotein complexes form a gel in the cytoplasm determining the conditions for translation... Photoreceptor stimulation involves two phases, trapping of light by a light reflecting cylinder formed by the outer segment disks and energy transduction by bleaching of photopigment molecules changing the charge of the outer segment disks driving the photoreceptor toward hyperpolarization. Revealing the synaptic connections between retinal neurons extends neurophysiology to the level of information processing by neural circuits, which are designed for high speed processing. Spatial brightness contrast enhancement is eliminated in connection with macular degeneration, which leads to partial blindness, revealing the importance of contrast enhancement for vision.
- Subjects :
- Adenosine Diphosphate physiology
Adenosine Triphosphate biosynthesis
Animals
Cell Respiration physiology
Cytoplasm chemistry
Cytoplasm ultrastructure
Freeze Fracturing methods
History, 20th Century
Humans
Intracellular Membranes enzymology
Macular Degeneration pathology
Macular Degeneration physiopathology
Mitochondria enzymology
Multienzyme Complexes physiology
Neurons, Afferent physiology
Neurons, Afferent ultrastructure
Phosphorylation
Photoreceptor Cells physiology
Photoreceptor Cells ultrastructure
Ribonucleoproteins analysis
Ribonucleoproteins ultrastructure
Synapses physiology
Synapses ultrastructure
Artifacts
Intracellular Membranes ultrastructure
Microscopy, Electron, Transmission history
Microscopy, Electron, Transmission methods
Mitochondria ultrastructure
Multienzyme Complexes ultrastructure
Subjects
Details
- Language :
- English
- ISSN :
- 1165-158X
- Volume :
- 51
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cellular and molecular biology (Noisy-le-Grand, France)
- Publication Type :
- Academic Journal
- Accession number :
- 16359627