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Reduced immunoregulatory CD31+ T cells in patients with atherosclerotic abdominal aortic aneurysm.
- Source :
-
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2006 Mar; Vol. 26 (3), pp. 618-23. Date of Electronic Publication: 2005 Dec 15. - Publication Year :
- 2006
-
Abstract
- Background: Cell-mediated immunity is considered to contribute to the pathogenesis of abdominal aortic aneurysms (AAA). In particular, infiltrating macrophages and CD8+ T lymphocytes participate in the destruction of the aortic wall extracellular matrix and smooth muscle cells. We surmise that these pathological events are controlled by circulating regulatory lymphocytes.<br />Methods and Results: Circulating CD4+/CD31+ cells were reduced in AAA patients (n=80, 8.9+/-0.6%) as compared with controls (n=69, 13.7+/-0.8%; P<0.001) and inversely proportional to AAA size. Exclusion of the aneurysm by an endoprothesis did not affect CD31+ T cell values. Reduction of blood CD4+/CD31+ cells was not attributable to their enrichment in AAA tissue. In contrast, CD8+/CD31+ cells were slightly reduced in the blood while increased in the aneurysmal tissue (29.2+/-0.5 versus 20.2+/-4.7% in blood, n=6; P<0.05). Remarkably, high percentages of CD4+/CD31+ cells were able to regulate proliferation and cytokine production of CD8+ lymphocytes, as well as CD8+ cell-mediated cytotoxicity of aortic smooth muscle cells (P<0.01). Finally, CD4+/CD31+ cells reduced the production and activity of metalloproteinase-9 by lipopolysaccharide-stimulated macrophages.<br />Conclusions: Circulating CD4+/CD31+ T cells regulate macrophage and CD8+ T cell activation and effector function in the arterial wall. Their reduction might promote the development of AAA.
- Subjects :
- Aged
Aged, 80 and over
Aortic Aneurysm, Abdominal pathology
Atherosclerosis pathology
CD4-CD8 Ratio
CD4-Positive T-Lymphocytes metabolism
CD8-Positive T-Lymphocytes immunology
Female
Humans
Lymphocyte Activation immunology
Macrophages immunology
Male
Middle Aged
Aortic Aneurysm, Abdominal immunology
Atherosclerosis immunology
CD4-Positive T-Lymphocytes immunology
Platelet Endothelial Cell Adhesion Molecule-1 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4636
- Volume :
- 26
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Arteriosclerosis, thrombosis, and vascular biology
- Publication Type :
- Academic Journal
- Accession number :
- 16357310
- Full Text :
- https://doi.org/10.1161/01.ATV.0000200380.73876.d9