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The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C.
- Source :
-
Science (New York, N.Y.) [Science] 2006 Jan 13; Vol. 311 (5758), pp. 230-2. Date of Electronic Publication: 2005 Dec 15. - Publication Year :
- 2006
-
Abstract
- The Prader-Willi syndrome is a congenital disease that is caused by the loss of paternal gene expression from a maternally imprinted region on chromosome 15. This region contains a small nucleolar RNA (snoRNA), HBII-52, that exhibits sequence complementarity to the alternatively spliced exon Vb of the serotonin receptor 5-HT(2C)R. We found that HBII-52 regulates alternative splicing of 5-HT(2C)R by binding to a silencing element in exon Vb. Prader-Willi syndrome patients do not express HBII-52. They have different 5-HT(2C)R messenger RNA (mRNA) isoforms than healthy individuals. Our results show that a snoRNA regulates the processing of an mRNA expressed from a gene located on a different chromosome, and the results indicate that a defect in pre-mRNA processing contributes to the Prader-Willi syndrome.
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 311
- Issue :
- 5758
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 16357227
- Full Text :
- https://doi.org/10.1126/science.1118265