Idiopathic hypereosinophilic syndrome in children: report of a 7-year-old boy with FIP1L1-PDGFRA rearrangement.

Authors :: Rives S
Alcorta I
Toll T
Tuset E
Estella J
Cross NC
Source :: Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2005 Dec; Vol. 27 (12), pp. 663-5.
Publication Year :: 2005
Abstract: Idiopathic hypereosinophilic syndrome (HES) in children is a very rare disorder; certain clinical differences with adult HES have been described, with no pediatric case with the imatinib-responsive FIP1L1-PDGFRA fusion gene reported to date. The authors describe the clinical course of three children with HES in whom FIP1L1-PDGFRA fusion gene was studied and report the first child with this rearrangement.

Subjects :: Adolescent
Anti-Inflammatory Agents therapeutic use
Child
Female
Humans
Hypereosinophilic Syndrome drug therapy
Hypereosinophilic Syndrome epidemiology
Male
Prednisone therapeutic use
Recurrence
Hypereosinophilic Syndrome genetics
Oncogene Proteins, Fusion genetics
Receptor, Platelet-Derived Growth Factor alpha genetics
mRNA Cleavage and Polyadenylation Factors genetics

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