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Determinants of health-related quality of life in women with vertebral fractures.
- Source :
-
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [Osteoporos Int] 2006; Vol. 17 (3), pp. 355-63. Date of Electronic Publication: 2005 Dec 09. - Publication Year :
- 2006
-
Abstract
- Health-related quality of life (HRQL) is an important consideration in the management of patients with vertebral fractures. The purpose of this study was to examine patient-related factors that contribute to HRQL after vertebral fractures, including co-morbidities, medications, fracture history, family disease history, demographics, exercise, education and living environment. A total of 1,129 post-menopausal women (mean age 67.2, SD 11.9 years) was studied from the Canadian Database of Osteoporosis and Osteopenia (CANDOO). HRQL was measured using the mini-osteoporosis quality of life questionnaire (mini-OQLQ). Separate multivariable linear regression analyses [parameter estimates and corresponding 95% confidence intervals (CI)] were performed for each of the five mini-OQLQ domains: symptoms, physical functioning, emotional functioning, activities of daily living and leisure domains. A strong positive association was found between HRQL and post-secondary education, a family history of osteoporosis, working and thiazide therapy. Exercise improved HRQL; however, several hours a week were required to be meaningful. Living in long-term care had the most marked negative effect on HRQL. Smoking, past surgery of the hip or spine, sedatives, anticonvulsants, atherosclerotic disease and hypertension were also associated with a substantially decreased HRQL across several domains. Calcium channel-blockers, chemotherapy, corticosteroids, diabetes, migraines, the number of non-vertebral fractures and falls had a negative impact on selected domains. We demonstrated that several modifiable factors influence HRQL in patients with vertebral fractures, and physicians should be aware of these and other markers of reduced HRQL to enhance patient care.
- Subjects :
- Activities of Daily Living
Aged
Back Pain etiology
Calcium Channel Blockers therapeutic use
Canada
Cardiovascular Diseases complications
Cardiovascular Diseases psychology
Databases, Factual
Educational Status
Emotions
Estrogen Replacement Therapy
Female
Fractures, Spontaneous complications
Humans
Linear Models
Middle Aged
Osteoporosis, Postmenopausal complications
Smoking adverse effects
Spinal Fractures complications
Spinal Fractures genetics
Surveys and Questionnaires
Thiazides therapeutic use
Health Status
Quality of Life
Spinal Fractures psychology
Subjects
Details
- Language :
- English
- ISSN :
- 0937-941X
- Volume :
- 17
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
- Publication Type :
- Academic Journal
- Accession number :
- 16341623
- Full Text :
- https://doi.org/10.1007/s00198-005-2020-3