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A candidate gene approach to searching for low-penetrance breast and prostate cancer genes.
- Source :
-
Nature reviews. Cancer [Nat Rev Cancer] 2005 Dec; Vol. 5 (12), pp. 977-85. - Publication Year :
- 2005
-
Abstract
- Most cases of breast and prostate cancer are not associated with mutations in known high-penetrance genes, indicating the involvement of multiple low-penetrance risk alleles. Studies that have attempted to identify these genes have met with limited success. The National Cancer Institute Breast and Prostate Cancer Cohort Consortium--a pooled analysis of multiple large cohort studies with a total of more than 5,000 cases of breast cancer and 8,000 cases of prostate cancer--was therefore initiated. The goal of this consortium is to characterize variations in approximately 50 genes that mediate two pathways that are associated with these cancers--the steroid-hormone metabolism pathway and the insulin-like growth factor signalling pathway--and to associate these variations with cancer risk.
Details
- Language :
- English
- ISSN :
- 1474-175X
- Volume :
- 5
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Nature reviews. Cancer
- Publication Type :
- Review
- Accession number :
- 16341085
- Full Text :
- https://doi.org/10.1038/nrc1754