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A candidate gene approach to searching for low-penetrance breast and prostate cancer genes.

Authors :
Hunter DJ
Riboli E
Haiman CA
Albanes D
Altshuler D
Chanock SJ
Haynes RB
Henderson BE
Kaaks R
Stram DO
Thomas G
Thun MJ
Blanché H
Buring JE
Burtt NP
Calle EE
Cann H
Canzian F
Chen YC
Colditz GA
Cox DG
Dunning AM
Feigelson HS
Freedman ML
Gaziano JM
Giovannucci E
Hankinson SE
Hirschhorn JN
Hoover RN
Key T
Kolonel LN
Kraft P
Le Marchand L
Liu S
Ma J
Melnick S
Pharaoh P
Pike MC
Rodriguez C
Setiawan VW
Stampfer MJ
Trapido E
Travis R
Virtamo J
Wacholder S
Willett WC
Source :
Nature reviews. Cancer [Nat Rev Cancer] 2005 Dec; Vol. 5 (12), pp. 977-85.
Publication Year :
2005

Abstract

Most cases of breast and prostate cancer are not associated with mutations in known high-penetrance genes, indicating the involvement of multiple low-penetrance risk alleles. Studies that have attempted to identify these genes have met with limited success. The National Cancer Institute Breast and Prostate Cancer Cohort Consortium--a pooled analysis of multiple large cohort studies with a total of more than 5,000 cases of breast cancer and 8,000 cases of prostate cancer--was therefore initiated. The goal of this consortium is to characterize variations in approximately 50 genes that mediate two pathways that are associated with these cancers--the steroid-hormone metabolism pathway and the insulin-like growth factor signalling pathway--and to associate these variations with cancer risk.

Details

Language :
English
ISSN :
1474-175X
Volume :
5
Issue :
12
Database :
MEDLINE
Journal :
Nature reviews. Cancer
Publication Type :
Review
Accession number :
16341085
Full Text :
https://doi.org/10.1038/nrc1754