[Hypertensive syndrome and changes of water-salt metabolism in the OXYS rats with early ageing].

Peculiarities of drinking behavior and ion deposit capacity have been studied in Wistar and OXYS rats using chronic salt loading. Increased arterial blood pressure in OXYS as compared with Wistar rats has been registered already in the age of 1.5 months. The difference between the two lines persisted up to the age of 18 months. Differences in drinking behavior were also detected: saline consumption in Wistar rats was increased up to 99 ml/day, whereas the OXYS rats revealed a diminished salt appetite. It has been found that tissues of the OXYS rats were characterized by pronounced ion deposit capacity under standard diet conditions as well as after intensive sodium input.