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Sexual behaviour and human herpesvirus 8 infection in homosexual men in Australia.
- Source :
-
Sexual health [Sex Health] 2005; Vol. 2 (1), pp. 13-8. - Publication Year :
- 2005
-
Abstract
- Background: Human herpesvirus 8 (HHV-8) is a common sexually transmitted agent among homosexual men, but there are few Australian data. We aimed to describe the prevalence and risk factors for seropositivity to HHV-8 in Australian homosexual men.<br />Methods: We conducted a prospective cohort study of 179 homosexual men in Sydney Australia in 1992-1998. Detailed data on sexual behaviour was collected annually, and HHV-8 status was determined at the end of the study by an algorithm based on results of an immunofluorescence assay and an enzyme-linked immunoassay to the K8.1 protein of HHV-8. HHV-8 DNA was detected in buffy coats using a nested qualitative PCR.<br />Results: Data on sexual behaviour in at least three interviews and HHV-8 status were available in 174 (97%) of 179 men who agreed to participate. Of these, 31 (18%) were HHV-8 seropositive, and HHV-8 DNA was detected in 5 (16%) of these. The prevalence of HHV-8 infection was much higher in HIV positive (52%) than HIV negative (11%) men (OR 8.60, 95% CI 3.55-20.86). HHV-8 infection was related to more frequent reporting of unprotected receptive anal sex (OR for most frequent versus least frequent category 3.03, 95% CI 1.01-9.03, P trend 0.02), insertive oro-anal sex (OR for most frequent v. least frequent category 3.02, 95% CI 1.15-7.93, P trend 0.02) and receptive oro-anal sex (OR for most frequent v. least frequent category 3.09, 95% CI 1.11-8.60, P trend 0.05) with casual partners.<br />Conclusions: These data are consistent with sexual transmission of HHV-8, but the precise mode of HHV-8 transmission remains unclear. Studies to elucidate the precise mode of sexual transmission of HHV-8 need to focus on potential salivary transmission, and should collect data on the HHV-8 infection and excretion status of the sexual partner.
- Subjects :
- Adult
Cohort Studies
DNA, Viral blood
Herpesviridae Infections blood
Herpesviridae Infections virology
Humans
Male
Multivariate Analysis
New South Wales epidemiology
Odds Ratio
Prospective Studies
Risk Factors
Risk-Taking
Seroepidemiologic Studies
Herpesviridae Infections epidemiology
Herpesvirus 8, Human isolation & purification
Homosexuality, Male statistics & numerical data
Unsafe Sex statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1448-5028
- Volume :
- 2
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Sexual health
- Publication Type :
- Academic Journal
- Accession number :
- 16334707
- Full Text :
- https://doi.org/10.1071/sh04029