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Preventive action of food seasoning spices mixture on fructose-induced lipid abnormalities.
- Source :
-
Asia Pacific journal of clinical nutrition [Asia Pac J Clin Nutr] 2005; Vol. 14 (4), pp. 420-7. - Publication Year :
- 2005
-
Abstract
- High fructose feeding in rats induces insulin resistance, hyperinsulinemia, hyperglycemia and dyslipidemia. The present study was undertaken to determine the hypolipidemic effect of food seasoning spices mixture on fructose-fed insulin resistant rats. Male Wistar rats received a daily diet containing either 60% fructose or 60% starch. They were administered with the spices mixture at three different doses (10 mg, 30 mg or 50 mg/day/rat) orally 15 days later. At the end of 45 days of the experimental period fructose-fed rats displayed elevated plasma glucose and insulin levels and dyslipidemia which included elevated levels of cholesterol, triglycerides, free fatty acids, reduced high density lipoprotein cholesterol and increased very low density lipoprotein cholesterol. Alterations in tissue lipid levels were also observed. Simultaneous treatment with spices mixture along with fructose diet resulted in the normalization of plasma glucose and insulin levels and restoration of lipid levels in plasma and tissues. The insulin potentiating action of the active principles in these spices may contribute to the hypolipidemic effect of spices mixture in high fructose-fed rats.
- Subjects :
- Animals
Blood Glucose metabolism
Cholesterol blood
Dose-Response Relationship, Drug
Fructose pharmacology
Insulin blood
Insulin Resistance
Lipids blood
Lipoproteins blood
Male
Random Allocation
Rats
Rats, Wistar
Triglycerides blood
Blood Glucose drug effects
Hyperlipidemias drug therapy
Hypolipidemic Agents pharmacology
Lipid Metabolism drug effects
Plant Extracts pharmacology
Spices
Subjects
Details
- Language :
- English
- ISSN :
- 0964-7058
- Volume :
- 14
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Asia Pacific journal of clinical nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 16326650