Back to Search
Start Over
Trypanosoma cruzi-induced molecular mimicry and Chagas' disease.
- Source :
-
Current topics in microbiology and immunology [Curr Top Microbiol Immunol] 2005; Vol. 296, pp. 89-123. - Publication Year :
- 2005
-
Abstract
- Chagas' disease, caused by Trypanosoma cruzi, has been considered a paradigm of infection-induced autoimmune disease. Thus, the scarcity of parasites in the chronic phase of the disease contrasts with the severe cardiac pathology observed in approximately 30% of chronic patients and suggested a role for autoimmunity as the origin of the pathology. Antigen-specific and antigen-non-specific mechanisms have been described by which T. cruzi infection might activate T and B cells, leading to autoimmunity. Among the first mechanisms, molecular mimicry has been claimed as the most important mechanism leading to autoimmunity and pathology in the chronic phase of this disease. In this regard, various T. cruzi antigens, such as B13, cruzipain and Cha, cross-react with host antigens at the B or T cell level and their role in pathogenesis has been widely studied. Immunization with those antigens and/or passive transfer of autoreactive T lymphocytes in mice lead to clinical disturbances similar to those found in Chagas' disease patients. On the other hand, the parasite is becoming increasingly detected in chronically infected hosts and may also be the cause of pathology either directly or through parasite-specific mediated inflammatory responses. Thus, the issue of autoimmunity versus parasite persistence as the cause of Chagas' disease pathology is hotly debated among many researchers in the field. We critically review here the evidence in favor of and against autoimmunity through molecular mimicry as responsible for Chagas' disease pathology from clinical, pathological and immunological perspectives.
- Subjects :
- Animals
Antigens, Protozoan immunology
Autoantigens immunology
Autoimmunity
B-Lymphocytes immunology
Chagas Cardiomyopathy etiology
Chagas Cardiomyopathy immunology
Chagas Cardiomyopathy parasitology
Chagas Disease immunology
Chagas Disease parasitology
Epitopes
Helminth Proteins immunology
Humans
Lymphocyte Activation
Myosins immunology
Protozoan Proteins immunology
Ribosomal Proteins immunology
T-Lymphocytes immunology
Trypanosoma cruzi growth & development
Trypanosoma cruzi pathogenicity
Chagas Disease etiology
Molecular Mimicry immunology
Trypanosoma cruzi immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0070-217X
- Volume :
- 296
- Database :
- MEDLINE
- Journal :
- Current topics in microbiology and immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16323421
- Full Text :
- https://doi.org/10.1007/3-540-30791-5_6