Effect of human neural progenitor cells on injured spinal cord.

Authors :: Xu GH
Bai JZ
Cai QL
Li XX
Li LS
Shen L
Source :: Chinese journal of traumatology = Zhonghua chuang shang za zhi [Chin J Traumatol] 2005 Dec; Vol. 8 (6), pp. 339-44.
Publication Year :: 2005
Abstract: Objective: To study whether human neural progenitor cells can differentiate into neural cells in vivo and improve the recovery of injured spinal cord in rats.<br />Methods: Human neural progenitor cells were transplanted into the injured spinal cord and the functional recovery of the rats with spinal cord contusion injury was evaluated with Basso-Beattie-Bresnahan (BBB) locomotor scale and motor evoked potentials. Additionally, the differentiation of human neural progenitor cells was shown by immunocytochemistry.<br />Results: Human neural progenitor cells developed into functional cells in the injured spinal cord and improved the recovery of injured spinal cord in both locomotor scores and electrophysiological parameters in rats.<br />Conclusions: Human neural progenitor cells can treat injured spinal cord, which may provide a new cell source for research of clinical application.

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