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Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2006 Apr 01; Vol. 14 (7), pp. 2375-85. Date of Electronic Publication: 2005 Nov 28. - Publication Year :
- 2006
-
Abstract
- Analogs of the antibiotic fosmidomycin, an inhibitor of the methylerythritol phosphate pathway to isoprenoids, were synthesized and evaluated against the recombinant Synechocystis sp. PCC6803 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR). Fosfoxacin, the phosphate analog of fosmidomycin, and its acetyl congener were found to be more potent inhibitors of DXR than fosmidomycin.
- Subjects :
- Fosfomycin chemical synthesis
Fosfomycin chemistry
Fosfomycin pharmacology
Molecular Structure
Structure-Activity Relationship
Synechocystis classification
Synechocystis drug effects
Aldose-Ketose Isomerases antagonists & inhibitors
Fosfomycin analogs & derivatives
Multienzyme Complexes antagonists & inhibitors
Oxidoreductases antagonists & inhibitors
Synechocystis enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 0968-0896
- Volume :
- 14
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 16310360
- Full Text :
- https://doi.org/10.1016/j.bmc.2005.11.012