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Aneuploidy of chromosome 8 and C-MYC amplification in individuals from northern Brazil with gastric adenocarcinoma.
- Source :
-
Anticancer research [Anticancer Res] 2005 Nov-Dec; Vol. 25 (6B), pp. 4069-74. - Publication Year :
- 2005
-
Abstract
- Background: Gastric cancer is the third most frequent type of neoplasia. In northern Brazil, the State of Pará has a high incidence of this type of neoplasia. Limited data are available so far on the genetic events involved in this disease.<br />Materials and Methods: Dual-color fluorescence in situ hybridization (FISH) for the C-MYC gene and chromosome 8 centromere was performed in 11 gastric adenocarcinomas.<br />Results: All cases showed aneuploidy of chromosome 8 and C-MYC amplification, in both the diffuse and the intestinal histopathological types of Laurén. No correlation was found between polysomy 8 and the histopathological characteristics of the tumors. C-MYC amplification, like homogeneously-stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Translocation of C-MYC was observed only in the diffuse-type.<br />Conclusion: Chromosome 8 can be used as a marker in the diagnosis of gastric adenocarcinoma. The C-MYC oncogene requires further studies in order to verify if it is, when amplified, an etiological cause of transformation or a consequence of the proliferation process.
- Subjects :
- Adenocarcinoma blood
Adult
Alleles
Brazil
Gene Amplification
Gene Rearrangement
Humans
In Situ Hybridization, Fluorescence
Lymphocytes ultrastructure
Male
Middle Aged
Stomach Neoplasms blood
Translocation, Genetic
Adenocarcinoma genetics
Aneuploidy
Chromosomes, Human, Pair 8 genetics
Genes, myc genetics
Stomach Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0250-7005
- Volume :
- 25
- Issue :
- 6B
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 16309200