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Aneuploidy of chromosome 8 and C-MYC amplification in individuals from northern Brazil with gastric adenocarcinoma.

Authors :
Calcagno DQ
Leal MF
Taken SS
Assumpção PP
Demachki S
Smith Mde A
Burbano RR
Source :
Anticancer research [Anticancer Res] 2005 Nov-Dec; Vol. 25 (6B), pp. 4069-74.
Publication Year :
2005

Abstract

Background: Gastric cancer is the third most frequent type of neoplasia. In northern Brazil, the State of Pará has a high incidence of this type of neoplasia. Limited data are available so far on the genetic events involved in this disease.<br />Materials and Methods: Dual-color fluorescence in situ hybridization (FISH) for the C-MYC gene and chromosome 8 centromere was performed in 11 gastric adenocarcinomas.<br />Results: All cases showed aneuploidy of chromosome 8 and C-MYC amplification, in both the diffuse and the intestinal histopathological types of Laurén. No correlation was found between polysomy 8 and the histopathological characteristics of the tumors. C-MYC amplification, like homogeneously-stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Translocation of C-MYC was observed only in the diffuse-type.<br />Conclusion: Chromosome 8 can be used as a marker in the diagnosis of gastric adenocarcinoma. The C-MYC oncogene requires further studies in order to verify if it is, when amplified, an etiological cause of transformation or a consequence of the proliferation process.

Details

Language :
English
ISSN :
0250-7005
Volume :
25
Issue :
6B
Database :
MEDLINE
Journal :
Anticancer research
Publication Type :
Academic Journal
Accession number :
16309200