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Technetium-99m-pyrophosphate kinetics and imaging in metabolic bone disease.
- Source :
-
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 1975 Jan; Vol. 16 (1), pp. 33-9. - Publication Year :
- 1975
-
Abstract
- A study was undertaken to investigate the behavior of 99mTc-Sn-pyrophosphate complex in metabolic bone disease. Of clinical importance was the generalized increased periarticular bone accumulation of the radiopharmaceutical in osteomalacia and in combined osteomalacia and osteitis fibrosa as found in patients with chronic renal failure. The pattern in primary hyperparathyroidism was variable. There was no correlation between the initial rates of accumulation of the radiophosphate complex or its bone to soft-tissue uptake ratio at 5 hr when compared with the degree of osteomalacia and osteitis fibrosa. It is postulated that the 99mTc-Sn-pyrophosphate complex has greater affinity for immature collagen than the crystal surface.
- Subjects :
- Adenocarcinoma complications
Adult
Aged
Anorexia Nervosa complications
Bone Diseases etiology
Female
Humans
Hyperparathyroidism complications
Hyperparathyroidism, Secondary complications
Middle Aged
Osteitis Deformans diagnosis
Osteitis Fibrosa Cystica diagnosis
Osteomalacia diagnosis
Parathyroid Neoplasms complications
Renal Dialysis adverse effects
Bone Diseases diagnosis
Diphosphates
Radionuclide Imaging
Technetium
Subjects
Details
- Language :
- English
- ISSN :
- 0161-5505
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 162946