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Effects of manganese on extracellular levels of dopamine in rat striatum: an analysis in vivo by brain microdialysis.
- Source :
-
Neurochemical research [Neurochem Res] 2005 Sep; Vol. 30 (9), pp. 1147-54. - Publication Year :
- 2005
-
Abstract
- The aim of this study is to determine the effects of intrastriatal administration of MnCl2, on the extracellular levels of dopamine (DA) and metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in basal conditions and stimulated by depolarization with KCl and pargyline administration. Also, we studied the effect of MnCl2 on extracellular levels of l-Dopa in the presence of aromatic amino acid decarboxylase (AADC) inhibitor 3-hydroxybencilhydracine-HCl (NSD 1015). This study concluded that MnCl2, reduced the basal and K+-stimulated DA-release in striatum, without notably affecting the DOPAC and HVA levels. Intraperitoneal injection of pargyline increased striatal DA levels, decreasing DOPAC and HVA levels. The infusion of MnCl2 removed the increase in DA levels, without affecting DOPAC and HVA levels. Perfusion of NSD 1015 increased the extracellular levels of L-DOPA in striatum, and MnCl2 increased the effect of NSD1015 on L-Dopa.
- Subjects :
- 3,4-Dihydroxyphenylacetic Acid metabolism
Animals
Aromatic Amino Acid Decarboxylase Inhibitors
Chlorides administration & dosage
Female
Homovanillic Acid metabolism
Hydrazines metabolism
Manganese Compounds administration & dosage
Monoamine Oxidase Inhibitors pharmacology
Pargyline pharmacology
Potassium Chloride metabolism
Rats
Rats, Sprague-Dawley
Visual Cortex chemistry
Visual Cortex drug effects
Chlorides metabolism
Dopamine metabolism
Extracellular Fluid chemistry
Manganese Compounds metabolism
Microdialysis
Visual Cortex metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0364-3190
- Volume :
- 30
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Neurochemical research
- Publication Type :
- Academic Journal
- Accession number :
- 16292508
- Full Text :
- https://doi.org/10.1007/s11064-005-7775-6