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Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat.
- Source :
-
Pain [Pain] 2005 Dec 05; Vol. 118 (3), pp. 327-335. Date of Electronic Publication: 2005 Nov 14. - Publication Year :
- 2005
-
Abstract
- The aim of the present study was to investigate the effects of cannabinoid agonists on established inflammatory hyperalgesia. We have compared the effects of pre-administration versus post-administration of a potent non-selective cannabinoid agonist HU210 and a selective CB2 receptor agonist JWH-133 on hindpaw weight bearing and paw oedema in the carrageenan model of inflammatory hyperalgesia. For comparative purposes we also determined the effects of the mu-opioid receptor agonist morphine and the COX2 inhibitor rofecoxib in this model. At 3 h following intraplantar injection of carrageenan (2%, 100 microl) there was a significant (P < 0.001) reduction in weight bearing on the ipsilateral hindpaw, compared to vehicle treated rats and a concomitant increase in ipsilateral hindpaw volume (P < 0.001), compared to vehicle treated rats. Systemic administration of HU210 (10 microg/kg) and JWH-133 (10 mg/kg) at 3 h following injection of carrageenan, significantly attenuated decreases in ipsilateral hindpaw weight bearing (P < 0.05 for both) and paw volume (P < 0.001 for both). Pre-administration of HU210 and JWH-133 had similar effects on weight bearing in this model. Pre-administered HU210 also significantly decreased carrageenan-induced changes in paw volume (P < 0.001), this was not the case for JWH-133. Effects of post-administered HU210 and JWH-133 on ipsilateral hindpaw weight bearing and paw volume were comparable to the effect of systemic post-administration of morphine and rofecoxib (3 mg/kg for both). In summary, both HU210 and JWH-133 attenuated established inflammatory hypersensitivity and swelling, suggesting that cannabinoid-based drugs have clinical potential for the treatment of established inflammatory pain responses.
- Subjects :
- Analgesics administration & dosage
Animals
Carrageenan
Dronabinol administration & dosage
Drug Combinations
Hyperalgesia etiology
Hyperalgesia prevention & control
Inflammation chemically induced
Inflammation complications
Inflammation physiopathology
Male
Rats
Treatment Outcome
Weight-Bearing
Cannabinoids administration & dosage
Dronabinol analogs & derivatives
Hyperalgesia drug therapy
Hyperalgesia physiopathology
Inflammation drug therapy
Receptor, Cannabinoid, CB1 agonists
Receptor, Cannabinoid, CB2 agonists
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3959
- Volume :
- 118
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Pain
- Publication Type :
- Academic Journal
- Accession number :
- 16289798
- Full Text :
- https://doi.org/10.1016/j.pain.2005.09.005