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New treatment regimes for virus-induced exacerbations of asthma.
- Source :
-
Pulmonary pharmacology & therapeutics [Pulm Pharmacol Ther] 2006; Vol. 19 (5), pp. 320-34. Date of Electronic Publication: 2005 Nov 10. - Publication Year :
- 2006
-
Abstract
- This review will focus on the role of viruses as causes of asthma exacerbations. The article will briefly review the current literature supporting this view, with a special focus on human rhinovirus (RV), the main virus associated with exacerbations of asthma. The review will then refer to possible strategies for treatment, and will include discussion on treatment with specific anti-viral therapy and type I interferon as a treatment for RV. The review will also include a discussion on current therapies for asthma, such as glucocorticosteroid and beta(2) agonist therapy alone and in combination and why this may be relevant to virus-induced exacerbations of asthma. Finally, the potential for future anti-inflammatory/immunomodulatory therapies with a focus on NF-kappaB inhibition will be discussed.
- Subjects :
- Adrenergic beta-Agonists therapeutic use
Anti-Inflammatory Agents therapeutic use
Antiviral Agents therapeutic use
Asthma physiopathology
Asthma virology
Glucocorticoids therapeutic use
Humans
Immunologic Factors therapeutic use
Interferon Type I therapeutic use
Respiratory Syncytial Viruses growth & development
Rhinovirus growth & development
Asthma drug therapy
Respiratory Syncytial Viruses drug effects
Rhinovirus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1094-5539
- Volume :
- 19
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Pulmonary pharmacology & therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 16289761
- Full Text :
- https://doi.org/10.1016/j.pupt.2005.09.005