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Modulation of glucose transporter (GLUT4) by vanadate and Trigonella in alloxan-diabetic rats.
- Source :
-
Life sciences [Life Sci] 2006 Jan 18; Vol. 78 (8), pp. 820-4. Date of Electronic Publication: 2005 Nov 14. - Publication Year :
- 2006
-
Abstract
- Oral administration of vanadate is an effective treatment for diabetes in animal models. However, vanadate exerts these effects at high doses and several toxic effects are produced. Low doses of vanadate are relatively safe but are unable to elicit any antidiabetic effect. The present study explored the prospect of using low doses of vanadate in combination with Trigonella seed powder (TSP) to evaluate their antidiabetic effect in alloxan-diabetic rats. Alloxan-diabetic rats were treated with insulin, vanadate, TSP and vanadate and TSP in combination for 3 weeks. The effect of these antidiabetic compounds was examined on general physiological parameters and distribution of glucose transporter (GLUT4) in skeletal muscle by immunoblotting and immunohistochemistry. Treatment of alloxan-diabetic rats with insulin, vanadate, TSP and vanadate in combination with TSP revived normoglycemia and restored the disturbances in the distribution of GLUT4 in skeletal muscle. TSP treatment was only partially effective in the restoration of diabetic alterations. The treatment of diabetic rats with combined doses of vanadate and TSP was most effective in the normalization of plasma glucose levels and correction of altered GLUT4 distribution.
- Subjects :
- Alloxan
Animals
Blood Glucose
Cell Fractionation
Diabetes Mellitus, Experimental metabolism
Dose-Response Relationship, Drug
Drug Therapy, Combination
Female
Hypoglycemic Agents pharmacokinetics
Insulin pharmacology
Muscle, Skeletal drug effects
Muscle, Skeletal metabolism
Muscle, Skeletal pathology
Plant Extracts pharmacokinetics
Plant Extracts therapeutic use
Rats
Rats, Wistar
Vanadates pharmacokinetics
Diabetes Mellitus, Experimental drug therapy
Glucose Transporter Type 4 metabolism
Hypoglycemic Agents therapeutic use
Trigonella chemistry
Vanadates therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0024-3205
- Volume :
- 78
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 16289562
- Full Text :
- https://doi.org/10.1016/j.lfs.2005.05.105