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[Blood culture negative endocarditis: a diagnostic challenge].

Authors :
Wälli F
Chuard C
Regamey C
Source :
Revue medicale suisse [Rev Med Suisse] 2005 Oct 12; Vol. 1 (36), pp. 2346-50.
Publication Year :
2005

Abstract

Blood culture negative endocarditis (BCNE) account for about 5% of all cases of endocarditis. Diagnosis and initiation of antimicrobial therapy may be delayed, with a negative impact on clinical outcome. The most common cause of BCNE is antimicrobial drug therapy before blood sampling. Other common causes include slow growing and non cultivable organisms. Identification of the etiologic agent is critical in the management of BCNE and molecular tools such as broad range 16SrRNA PCR technique followed by direct automated sequencing and microorganism-specific PCR are promising. Some authors have proposed to include these techniques among major Duke's criteria for the diagnosis of BCNE.

Details

Language :
French
ISSN :
1660-9379
Volume :
1
Issue :
36
Database :
MEDLINE
Journal :
Revue medicale suisse
Publication Type :
Academic Journal
Accession number :
16281446