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[Fusion and apoptosis of epithelial cells induced by muramidase released protein of Streptococcus suis type 2].
- Source :
-
Wei sheng wu xue bao = Acta microbiologica Sinica [Wei Sheng Wu Xue Bao] 2003 Jun; Vol. 43 (3), pp. 407-12. - Publication Year :
- 2003
-
Abstract
- The pathogenic role of muramidase released protein (MRP), a virulence factor of Streptococcus suis type 2 (SS2) is poorly understood. The purified MRP was co-incubated with HEp-2 cells to determine the effect of MRP on epithelial cells. Under light microscope, two principal morphologic changes were observed. Firstly, the cells were fused to form syncytia and a apoptosis followed. Secondly, single cell was also induced to apoptosis at high level as 18%, which was verified by transmission electron microscopy and flow cytometry. It showed that MRP alone was capable of a virulence factor of SS2.
- Subjects :
- Cell Fusion
Cell Line
Epithelial Cells drug effects
Humans
Streptococcus suis chemistry
Virulence Factors pharmacology
Antigens, Bacterial pharmacology
Apoptosis drug effects
Bacterial Proteins pharmacology
Epithelial Cells cytology
Streptococcal Infections microbiology
Streptococcus suis metabolism
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0001-6209
- Volume :
- 43
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Wei sheng wu xue bao = Acta microbiologica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 16279210