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Frictional properties of regenerated cartilage in vitro.
- Source :
-
Journal of biomechanics [J Biomech] 2006; Vol. 39 (1), pp. 103-9. Date of Electronic Publication: 2004 Dec 29. - Publication Year :
- 2006
-
Abstract
- Although tribological function is the most important mechanical property of articular cartilage, few studies have examined this function in tissue-engineered cartilage. We investigated changes in the frictional properties of cartilage regenerated from the inoculation of rabbit chondrocytes into fibroin sponge. A reciprocating friction-testing apparatus was used to measure the friction coefficient of the regenerated cartilage under a small load. The specimen was slid against a stainless steel plate in a water vessel filled with physiological saline. The applied load was 0.03 N, the stroke length was 20 mm, and the mean sliding velocity was 0.8 mm/s. The friction coefficient of the regenerated cartilage decreased with increasing cultivation time, because a hydrophilic layer of synthesized extracellular matrix was formed on the fibroin sponge surface. The friction coefficient of the regenerated cartilage was as low as that of natural cartilage in the early stages of the sliding tests, but it increased with increasing duration of sliding owing to exudation of interstitial water from the surface layer.
- Subjects :
- Animals
Cartilage, Articular ultrastructure
Chondrocytes ultrastructure
Elasticity
Fibroins chemistry
Friction
Glycosaminoglycans metabolism
Hydrogel, Polyethylene Glycol Dimethacrylate chemistry
Microscopy, Electron, Scanning
Rabbits
Stress, Mechanical
Tissue Engineering
Viscosity
Cartilage, Articular physiology
Chondrocytes physiology
Regeneration physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9290
- Volume :
- 39
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of biomechanics
- Publication Type :
- Academic Journal
- Accession number :
- 16271593
- Full Text :
- https://doi.org/10.1016/j.jbiomech.2004.10.031