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Claudin proteins in human cancer: promising new targets for diagnosis and therapy.

Authors :
Morin PJ
Source :
Cancer research [Cancer Res] 2005 Nov 01; Vol. 65 (21), pp. 9603-6.
Publication Year :
2005

Abstract

The tight junction proteins claudins are abnormally regulated in several human cancers. In particular, claudin-3 and claudin-4 are frequently overexpressed in several neoplasias, including ovarian, breast, pancreatic, and prostate cancers. Although the exact roles of these proteins in tumorigenesis are still being uncovered, it is clear that they represent promising targets for cancer detection, diagnosis, and therapy.

Details

Language :
English
ISSN :
0008-5472
Volume :
65
Issue :
21
Database :
MEDLINE
Journal :
Cancer research
Publication Type :
Academic Journal
Accession number :
16266975
Full Text :
https://doi.org/10.1158/0008-5472.CAN-05-2782