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Theoretical optimization by genetic algorithm of delayed extraction parameters for a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer.
- Source :
-
Rapid communications in mass spectrometry : RCM [Rapid Commun Mass Spectrom] 2005; Vol. 19 (23), pp. 3457-62. - Publication Year :
- 2005
-
Abstract
- This paper presents the application of a genetic algorithm (GA) to optimize the operating parameters, namely pulse voltage and extraction delay time, when using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOFMS). Simulations predict the presence of several combinations of these parameters that give a local maximum. The aim is to locate the optimal combination (a global maximum) of pulse voltage and extraction time delay in order to focus the ions of a particular m/z value to achieve the best resolution in a given instrumental geometry. The GA locates the global maximum quickly. The results indicate that it may be possible to achieve very high resolving power by using delayed extraction (DE)-MALDI-TOFMS with parameters obtained from the GA.
Details
- Language :
- English
- ISSN :
- 0951-4198
- Volume :
- 19
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Rapid communications in mass spectrometry : RCM
- Publication Type :
- Academic Journal
- Accession number :
- 16261640
- Full Text :
- https://doi.org/10.1002/rcm.2219