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The structural brain correlates of neurological soft signs in healthy individuals.
- Source :
-
Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2006 Aug; Vol. 16 (8), pp. 1225-31. Date of Electronic Publication: 2005 Oct 26. - Publication Year :
- 2006
-
Abstract
- It has yet to be established whether neurological soft signs (NSS), which include poor motor coordination, sensory perceptual difficulties and difficulties in sequencing of complex motor tasks, result from specific or diffuse brain structural abnormalities. Studying the neuroanatomical basis of NSS in healthy individuals may help to identify which brain areas are specifically associated with these signs, while excluding the potential confounding effects of psychiatric and neurological disorders. We investigated the relationship between brain structure and NSS in 43 healthy individuals, using the Neurological Evaluation Scale for neurological assessment, and high resolution MRI and voxel-based methods of image analysis to investigate brain structure. Higher rates of NSS were associated with a reduction of inferior frontal gyrus, middle and superior temporal gyrus, and anterior cingulate gyrus. It is of note that in a previous study of patients with psychosis we found that an excess of NSS was associated with a reduction of similar cortical areas. Therefore, we suggest that these cortical brain structural changes represent a common neuroanatomical substrate of NSS, across healthy individuals and patients with psychosis.
- Subjects :
- Adolescent
Adult
Aged
Female
Humans
Male
Middle Aged
Nervous System Diseases pathology
Nervous System Diseases physiopathology
Nervous System Diseases psychology
Neuropsychological Tests
Brain pathology
Neurologic Examination methods
Psychotic Disorders pathology
Psychotic Disorders psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1047-3211
- Volume :
- 16
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cerebral cortex (New York, N.Y. : 1991)
- Publication Type :
- Academic Journal
- Accession number :
- 16251504
- Full Text :
- https://doi.org/10.1093/cercor/bhj063