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Effect of benzodiazepine hypnotic triazolam on relationship of blood pressure and Paco2 to cerebral blood flow during human non-rapid eye movement sleep.
- Source :
-
Journal of neurophysiology [J Neurophysiol] 2006 Apr; Vol. 95 (4), pp. 2293-303. Date of Electronic Publication: 2005 Oct 26. - Publication Year :
- 2006
-
Abstract
- We sought to clarify the effect of short-acting benzodiazepine hypnotic on the relationship of arterial blood pressure and arterial partial pressure of carbon dioxide (Paco2) to regional cerebral blood flow (rCBF) during human non-rapid-eye-movement (non-REM) sleep. Nine young normal volunteers were treated in a randomized, crossover design with triazolam or placebo and underwent positron emission tomography at night. During wakefulness and stage 2 and slow wave (stages 3 and 4) sleep, we measured mean arterial blood pressure (MAP), Paco2, and absolute CBF. With triazolam compared to placebo, MAP reduced gradually. During stage 2 sleep, Paco2 increased and whole-brain mean CBF decreased. With triazolam, relative rCBF of the left orbital basal forebrain decreased more during stage 2 than slow wave sleep, whereas absolute CBF of the occipital cortex and cerebral white matter remained constant. During triazolam-induced stage 2 sleep, absolute CBF of the cerebral white matter correlated more strongly to both MAP and Paco2 than during placebo sleep and also correlated more strongly to both MAP and Paco2 than absolute CBF of the occipital cortex. In the frontal white matter, during triazolam-induced stage 2 sleep compared to wakefulness, absolute CBF was significantly better correlated to MAP, but not to Paco2. During triazolam-induced stage 2, the cerebral white matter may receive a modulated CBF regulation having the strengthened relationship of Paco2 to CBF and, more locally, the frontal white matter may depend precariously on CBF regulation.
- Subjects :
- Adult
Blood Gas Monitoring, Transcutaneous
Blood Pressure physiology
Brain diagnostic imaging
Cross-Over Studies
Eye Movements physiology
Frontal Lobe blood supply
Humans
Male
Occipital Lobe blood supply
Partial Pressure
Positron-Emission Tomography
Regional Blood Flow drug effects
Sleep drug effects
Sleep Stages drug effects
Sleep Stages physiology
Blood Pressure drug effects
Carbon Dioxide blood
Cerebrovascular Circulation drug effects
Hypnotics and Sedatives pharmacology
Sleep physiology
Triazolam pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3077
- Volume :
- 95
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of neurophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 16251267
- Full Text :
- https://doi.org/10.1152/jn.00114.2005