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Efficient chemo-enzymatic syntheses of pharmaceutically useful unnatural 2'-deoxynucleosides.
- Source :
-
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2005; Vol. 24 (5-7), pp. 1127-30. - Publication Year :
- 2005
-
Abstract
- Our chemo-enzymatic method was successfully applied to the synthesis of 2-chloro-2'-deoxyadenosine (CdA, cladribine) in two ways: 1) direct conversion of chemically synthesized 2-deoxy-alpha-D-ribose 1-phosphate (dRP) to CdA; 2) a two-step route via 9-(2-deoxy-beta-D-ribos-1-yl)-2, 6-dichloropurine (Cl2Pu-dR, 5).
- Subjects :
- Antineoplastic Agents pharmacology
Cladribine pharmacology
Glycosylation
Models, Chemical
Nucleosides chemistry
Nucleotides chemistry
Phosphates chemistry
Purine-Nucleoside Phosphorylase chemistry
Antineoplastic Agents chemical synthesis
Cladribine chemical synthesis
Nucleosides chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1525-7770
- Volume :
- 24
- Issue :
- 5-7
- Database :
- MEDLINE
- Journal :
- Nucleosides, nucleotides & nucleic acids
- Publication Type :
- Academic Journal
- Accession number :
- 16248106
- Full Text :
- https://doi.org/10.1081/ncn-200060154