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Interaction of porphyrin with G-quadruplex structures.

Authors :
Erra E
Petraccone L
Esposito V
Randazzo A
Mayol L
Ladbury J
Barone G
Giancola C
Source :
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2005; Vol. 24 (5-7), pp. 753-6.
Publication Year :
2005

Abstract

Isothermal titration calorimetry (ITC) is a sensitive technique for probing bimolecular processes and can provide direct information about the binding affinity and stoichiometry and the key thermodynamic parameters involved. ITC has been used to investigate the interaction of the ligand H2TMPyP to the two DNA quadruplexes, [d(AGGGT)]4 and [d(TGGGGT)]. Analysis of the ITC data reveals that porphyrin/quadruplex binding stoichiometry under saturating conditions is 1:2 for [d(AGGGT)]4 and 2:1 for [d(TGGGGT)], respectively.

Details

Language :
English
ISSN :
1525-7770
Volume :
24
Issue :
5-7
Database :
MEDLINE
Journal :
Nucleosides, nucleotides & nucleic acids
Publication Type :
Academic Journal
Accession number :
16248030
Full Text :
https://doi.org/10.1081/ncn-200060070