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[Cardiac ion channel disorders--diagnosis and treatment].
- Source :
-
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke [Tidsskr Nor Laegeforen] 2005 Oct 20; Vol. 125 (20), pp. 2778-81. - Publication Year :
- 2005
-
Abstract
- Background: Inherited arrhythmogenic disorders are a group of genetically determined diseases characterised by ventricular tachyarrhythmias sometimes leading to sudden death. The molecular bases of these disorders are mutations in genes coding for various cardiac ion channels. The most common cardiac ion channel disease is the long QT syndrome. This syndrome is rare, but probably more common in Norway than previously expected. We have recently started genetic testing for cardiac ion channel disorders at Rikshospitalet University Hospital in Oslo. This review describes the current understanding of the etiology, prognosis and management of cardiac ion channel disorders, based on literature and our own clinical experience.<br />Interpretation: Cardiac ion channel disorders may lead to sudden cardiac death. Prophylactic and life-saving therapies are available for many of these disorders. Therapy and risk stratification depend on the clinical presentation, the ECG pattern, and which gene is mutated. Genetic testing offers the opportunity to exclude individual family members as mutation carriers.
- Subjects :
- Adult
Bundle-Branch Block congenital
Bundle-Branch Block diagnosis
Bundle-Branch Block drug therapy
Bundle-Branch Block genetics
Child
Death, Sudden, Cardiac etiology
Death, Sudden, Cardiac prevention & control
Genetic Predisposition to Disease
Genetic Testing
Humans
Infant
Mutation
Phenotype
Potassium Channels genetics
Potassium Channels physiology
Prognosis
Risk Factors
Sodium Channels genetics
Sodium Channels physiology
Syndrome
Arrhythmias, Cardiac congenital
Arrhythmias, Cardiac diagnosis
Arrhythmias, Cardiac drug therapy
Arrhythmias, Cardiac genetics
Long QT Syndrome congenital
Long QT Syndrome diagnosis
Long QT Syndrome drug therapy
Long QT Syndrome genetics
Subjects
Details
- Language :
- Norwegian
- ISSN :
- 0807-7096
- Volume :
- 125
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
- Publication Type :
- Academic Journal
- Accession number :
- 16244679