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Review article: type 2 diabetes and chronic liver disease in the Verona diabetes study.
- Source :
-
Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2005 Nov; Vol. 22 Suppl 2, pp. 24-7. - Publication Year :
- 2005
-
Abstract
- Non-alcoholic liver steatosis is associated with metabolic syndrome and type 2 diabetes. The prevalence of this condition in type 2 diabetes is estimated to be between 28 and 55%. Non-alcoholic liver steatosis is not a benign disease because of its potential progression to liver fibrosis, cirrhosis and cancer. The Verona diabetes study, a population-based observational study, on 7148 type 2 diabetic patients after 5 years of follow-up has reported an increased risk of death from gastrointestinal diseases, particularly from chronic liver cirrhosis. Moreover, in the same population after 10 years of follow-up a higher risk of mortality from liver cancer was observed and this risk increased significantly in obese patients (body mass index >30 kg/m2). Of note is that obese diabetic patients suffer an even higher prevalence of non-alcoholic liver steatosis. In conclusion, the Verona diabetes study showed an increased risk of mortality from liver cirrhosis and liver cancer in type 2 diabetic patients. Diverse pathophysiological mechanisms can be responsible, i.e. higher alcohol consumption, hepatitis and others but, considering the high prevalence of non-alcoholic liver steatosis in these patients, it is plausible to hypothesize that non-alcoholic liver steatosis may play a significant role in predisposing the liver of diabetics to chronic diseases.
- Subjects :
- Chronic Disease
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 mortality
Fatty Liver complications
Fatty Liver epidemiology
Humans
Italy epidemiology
Liver Cirrhosis complications
Liver Cirrhosis epidemiology
Liver Cirrhosis mortality
Liver Diseases complications
Liver Diseases mortality
Liver Neoplasms complications
Liver Neoplasms epidemiology
Liver Neoplasms mortality
Obesity complications
Obesity epidemiology
Prevalence
Tumor Necrosis Factor-alpha metabolism
Diabetes Mellitus, Type 2 epidemiology
Liver Diseases epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 0269-2813
- Volume :
- 22 Suppl 2
- Database :
- MEDLINE
- Journal :
- Alimentary pharmacology & therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 16225467
- Full Text :
- https://doi.org/10.1111/j.1365-2036.2005.02590.x