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Induction of sharp wave-ripple complexes in vitro and reorganization of hippocampal networks.
- Source :
-
Nature neuroscience [Nat Neurosci] 2005 Nov; Vol. 8 (11), pp. 1560-7. Date of Electronic Publication: 2005 Oct 16. - Publication Year :
- 2005
-
Abstract
- Hippocampal sharp wave-ripple complexes (SPW-Rs) occur during slow-wave sleep and behavioral immobility and are thought to represent stored information that is transferred to the neocortex during memory consolidation. Here we show that stimuli that induce long-term potentiation (LTP), a neurophysiological correlate of learning and memory, can lead to the generation of SPW-Rs in rat hippocampal slices. The induced SPW-Rs have properties that are identical to spontaneously generated SPW-Rs: they originate in CA3, propagate to CA1 and subiculum and require AMPA/kainate receptors. Their induction is dependent on NMDA receptors and involves changes in interactions between clusters of neurons in the CA3 network. Their expression is blocked by low-frequency stimulation but not by NMDA receptor antagonists. These data indicate that induction of LTP in the recurrent CA3 network may facilitate the generation of SPW-Rs.
- Subjects :
- 6-Cyano-7-nitroquinoxaline-2,3-dione pharmacology
Action Potentials drug effects
Action Potentials physiology
Action Potentials radiation effects
Animals
Animals, Newborn
Carbenoxolone pharmacology
Dizocilpine Maleate pharmacology
Dose-Response Relationship, Radiation
Electric Stimulation methods
Excitatory Amino Acid Antagonists pharmacology
Female
Hippocampus physiology
In Vitro Techniques
Long-Term Potentiation drug effects
Long-Term Potentiation radiation effects
Male
Models, Neurological
Nerve Net cytology
Nerve Net drug effects
Neural Inhibition drug effects
Neural Inhibition physiology
Neural Inhibition radiation effects
Neurons classification
Neurons drug effects
Neurons radiation effects
Rats
Rats, Wistar
Receptors, Kainic Acid physiology
Uncoupling Agents pharmacology
Hippocampus cytology
Long-Term Potentiation physiology
Nerve Net physiology
Neurons physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6256
- Volume :
- 8
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Nature neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 16222227
- Full Text :
- https://doi.org/10.1038/nn1571